Roundtable Discussion: Navigating In Vivo Validation Challenges for Intracellular Therapeutics
Time: 4:30 pm
day: Day One
Details:
- Addressing key considerations in improving the transition from in vitro proof-of-concept to in vivo efficacy and safety with intracellular therapeutics
- Exploring the importance of distinguishing between what can and cannot be achieved, particularly in relation to delivery, efficacy, and safety aspects
- Discussing key gating milestones, criteria for selecting the initial in vivo animal model, and strategic approaches to bioavailability, biodistribution, and routes of administration in the context of targeting specific disease-related physiology
