RNA Medicines: Chemical Evolution of Synthetic Carriers
Time: 11:00 am
day: Day Two
Details:
- Precise carriers made of short sequences of artificial amino acids optimized by evolution cycles
- Highly effective cell entry and endosomal escape triggers fast and potent (>80%) siRNA, mRNA, Cas9/sgRNA and RNA LNP transfer at very low (~ 5-50 ng) dosage
- Highly efficient transfer (1μg mRNA/mouse) into tumor, spleen, muscle, liver, lung by mRNA polyplexes or LNPs
