Safe and Effective Delivery of Nucleic Acids Using Proteolipid Vehicles Formulated with Fusion-Associated Small Transmembrane Proteins
Time: 11:50 am
day: Day One
Details:
- Imagine an LNP that works like a virus, combining the best features of AAV and LNPs while overcoming the limitations of both platforms. Fusogenix Proteo Lipid Vehicles (PLVs) are the ideal, re-imagined lipid-based nanoparticles that deliver nucleic acid cargo to cells through direct plasma membrane fusion
- PLVs are formulated with an optimized, fully synthetic Fusion Associated Small Transmembrane (FAST) protein derived from fusogenic Orthoreoviruses
- FAST proteins are sufficient to enable fusion of the PLV with the target cell and delivery of the nucleic acid cargo.
- PLVs effectively deliver RNA and/or DNA to a wide array of extra-hepatic organs at high doses with little to no systemic toxicity
